Development and characterization of solid dispersion to enhance the dissolution profile of Nifedipine with PVP K30 and Poloxamer 407

The purpose of this study is to develop and characterize the nature of a solid dispersion system of nifedipine in a polymer matrix consisting of PVP K30 and poloxamer 407. Dispersions consist of drug, polymeric carrier and surfactant carrier. Binary solid dispersions consisting of nifedipine and PVP K30 were developed by solvent evaporation method. Poloxamer 407, surfactant carrier was incorporated into binary solid dispersions as the third component to prepare ternary solid dispersions. Solid dispersions were characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy, and dissolution tests. Both the binary and ternary solid dispersions enhanced the dissolution of nifedipine. Moreover, the dissolution of ternary solid dispersion was faster compared with that of binary solid dispersion. Poloxamer 407 played an important positive role in dissolution of the solid dispersion.